منابع مشابه
Calcineurin inhibitor nephrotoxicity.
The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome. However, the chronic nephrotoxicity of these drugs is the Achilles' heel of current immunosuppressive regimens. In this review, the authors summarize the clinical features and histologic appearance of both acute and chronic calcineurin inhib...
متن کاملPathophysiology and treatment of calcineurin inhibitor nephrotoxicity
and treatment of calcineurin inhibitor nephrotoxicity" (2014). All. Paper 2.
متن کاملCalcineurin inhibitor-induced renal allograft nephrotoxicity.
BACKGROUND The introduction of the calcineurin inhibitors (CI) cyclosporine and tacrolimus into immunosuppressive protocols initiated a new era in organ transplantation with excellent short-term graft survival. Nevertheless, the chronic nephrotoxicity of these drugs represents a significant adverse factor limiting their long-term use. Patients treated with a CI can be at risk for developing ren...
متن کاملMechanisms of Calcineurin Inhibitor Nephrotoxicity in Chronic Allograft Injury
The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between genetically identical twins and therefore immunosuppression was not necessary in this particular case (Merrill et al., 1956). However, solid-organ...
متن کاملDoes Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity?
Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fibrosis and tubular atrophy, which impairs long-term allograft survival. The mineralocorticoid hormone aldosterone induces fibrosis in numerous organ...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2009
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.04800908